PXF variations due to race, genetic, and/or geographical differences.

 PXF syndrome  shows an extensive variations in different
population— Eskimos 0%,5  in a south eastern US
population 1.6%6,7  Navajo Indians 38%.8  Blue Mountains Eye Study
estimates a prevalence of 2.3%.11 These showed true variations due
to race, genetic, and/or geographical differences.  Sood and Ratnaraj in 1968, showed 1.87%
prevalence PXFS in patients age below 45 years and  34% above 45 years 12  Lamba and Giridhar in 1984,13 who reported a 7.4% prevalence
of PXFS and 9% of  patients had glaucoma
among them. In our study
prevalence of PXF was 5.2 %.


reports  had shown an age-related
increase of PXF, it typically being less common below the age of 60 years and
increasing thereafter. We found similar results.

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We found no
significant association between male and female after adjusting for age.
Pseudoexfoliation has been reported  as
the most common cause for open-angle glaucoma.

The mean IOP in subjects with PXF was 19.42 (8.12)  mm Hg which was significantly higher than in
those without PXF.  Ocular hypertension
was found in 13.3% of cases with PEX which was higher than caes without PXF. This
difference was significant. Open angle glaucoma was found in 14.8% of PEX case
compared to 1.90% in non PXF cases which was significant. In a clinical based
study, Kozart and Yanoff,14  reported 15% prevalence of OHT
and 7% prevalence of glaucoma among PXF patients. The Blue Mountains Eye Study,11 a population based study was reported
9.3% OHT and 14.2% glaucoma. This data were comparable to our results

 In our study,we found
a 2.9% prevalence of narrow angles in cases with PEX. Layden and Schaffer3 found the prevalence of narrow
angles was 23% in 100 patients with PEX and Wishart et al4  was reported
18% .there is  a greater tendency to form
posterior synechiae by rigid and sticky iris, and anterior lens subluxation due
to zonular weakness , these are worsened by miotic therapy.

 Slit-lamp biomicroscopy and dilated
examinations  is required to detect Early
clinical signs. Clinical examination with slit-lamp biomicroscopy for anterior
segment  and fundus examinations for all
patients should be done unless otherwise contraindicated.

A major drawback of
our study was sample was small and taken as randomly that do not presume to project estimates for the
entire large and diverse country.  . The population studied was  rural and predominantly illiterate so many
patients not willing to return for a field examination and Only 18% performed
the field test  was reliably similar
problem shown by a population based study by Jacob et al . However, the optic disc was
carefully evaluated in all subjects 
,these factors may have led to underestimation of the prevalence of
glaucoma  which was not  significant