PXF syndrome shows an extensive variations in different
population— Eskimos 0%,5 in a south eastern US
population 1.6%6,7 Navajo Indians 38%.8 Blue Mountains Eye Study
estimates a prevalence of 2.3%.11 These showed true variations due
to race, genetic, and/or geographical differences. Sood and Ratnaraj in 1968, showed 1.87%
prevalence PXFS in patients age below 45 years and 34% above 45 years 12 Lamba and Giridhar in 1984,13 who reported a 7.4% prevalence
of PXFS and 9% of patients had glaucoma
among them. In our study
prevalence of PXF was 5.2 %.
reports had shown an age-related
increase of PXF, it typically being less common below the age of 60 years and
increasing thereafter. We found similar results.
We found no
significant association between male and female after adjusting for age.
Pseudoexfoliation has been reported as
the most common cause for open-angle glaucoma.
The mean IOP in subjects with PXF was 19.42 (8.12) mm Hg which was significantly higher than in
those without PXF. Ocular hypertension
was found in 13.3% of cases with PEX which was higher than caes without PXF. This
difference was significant. Open angle glaucoma was found in 14.8% of PEX case
compared to 1.90% in non PXF cases which was significant. In a clinical based
study, Kozart and Yanoff,14 reported 15% prevalence of OHT
and 7% prevalence of glaucoma among PXF patients. The Blue Mountains Eye Study,11 a population based study was reported
9.3% OHT and 14.2% glaucoma. This data were comparable to our results
In our study,we found
a 2.9% prevalence of narrow angles in cases with PEX. Layden and Schaffer3 found the prevalence of narrow
angles was 23% in 100 patients with PEX and Wishart et al4 was reported
18% .there is a greater tendency to form
posterior synechiae by rigid and sticky iris, and anterior lens subluxation due
to zonular weakness , these are worsened by miotic therapy.
Slit-lamp biomicroscopy and dilated
examinations is required to detect Early
clinical signs. Clinical examination with slit-lamp biomicroscopy for anterior
segment and fundus examinations for all
patients should be done unless otherwise contraindicated.
A major drawback of
our study was sample was small and taken as randomly that do not presume to project estimates for the
entire large and diverse country. . The population studied was rural and predominantly illiterate so many
patients not willing to return for a field examination and Only 18% performed
the field test was reliably similar
problem shown by a population based study by Jacob et al . However, the optic disc was
carefully evaluated in all subjects
,these factors may have led to underestimation of the prevalence of
glaucoma which was not significant