PXF variations due to race, genetic, and/or geographical differences.

 PXF syndrome  shows an extensive variations in differentpopulation— Eskimos 0%,5  in a south eastern USpopulation 1.6%6,7  Navajo Indians 38%.8  Blue Mountains Eye Studyestimates a prevalence of 2.

3%.11 These showed true variations dueto race, genetic, and/or geographical differences.  Sood and Ratnaraj in 1968, showed 1.87%prevalence PXFS in patients age below 45 years and  34% above 45 years 12  Lamba and Giridhar in 1984,13 who reported a 7.4% prevalenceof PXFS and 9% of  patients had glaucomaamong them. In our studyprevalence of PXF was 5.2 %.

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 Previousreports  had shown an age-relatedincrease of PXF, it typically being less common below the age of 60 years andincreasing thereafter. We found similar results.We found nosignificant association between male and female after adjusting for age.Pseudoexfoliation has been reported  asthe most common cause for open-angle glaucoma.The mean IOP in subjects with PXF was 19.

42 (8.12)  mm Hg which was significantly higher than inthose without PXF.  Ocular hypertensionwas found in 13.3% of cases with PEX which was higher than caes without PXF. Thisdifference was significant. Open angle glaucoma was found in 14.8% of PEX casecompared to 1.90% in non PXF cases which was significant.

In a clinical basedstudy, Kozart and Yanoff,14  reported 15% prevalence of OHTand 7% prevalence of glaucoma among PXF patients. The Blue Mountains Eye Study,11 a population based study was reported9.3% OHT and 14.2% glaucoma. This data were comparable to our results In our study,we founda 2.

9% prevalence of narrow angles in cases with PEX. Layden and Schaffer3 found the prevalence of narrowangles was 23% in 100 patients with PEX and Wishart et al4  was reported18% .there is  a greater tendency to formposterior synechiae by rigid and sticky iris, and anterior lens subluxation dueto zonular weakness , these are worsened by miotic therapy. Slit-lamp biomicroscopy and dilatedexaminations  is required to detect Earlyclinical signs. Clinical examination with slit-lamp biomicroscopy for anteriorsegment  and fundus examinations for allpatients should be done unless otherwise contraindicated.

A major drawback ofour study was sample was small and taken as randomly that do not presume to project estimates for theentire large and diverse country.  . The population studied was  rural and predominantly illiterate so manypatients not willing to return for a field examination and Only 18% performedthe field test  was reliably similarproblem shown by a population based study by Jacob et al . However, the optic disc wascarefully evaluated in all subjects ,these factors may have led to underestimation of the prevalence ofglaucoma  which was not  significant