Abstract: Presentlyscientist are innovatively using ‘omicsapproaches to screen the toxicity ofchemicals, in different categories of potential chemicals depending upon theirmode of action. Metabolomics is one ofthose omics including proteomics ,trancriptomics.It is an advancedand executable technique widely employedto analyze the interactions oforganisms with their environment for studying the stress induced by anthropogenicactivities. The pattern, or fingerprint, of metabolites (endogenous and exogenous low molecular mass chemicalswithin a cell, tissue, or biofluid) of an organism in response to an externalstressorto learn about the “health” of the organism. Pesticide are sprayed on crops to help them grow, butthe effect on earthworms living in the soil under the plants is devastating, Pyrethroids,subclass of pesticide ,are synthetic analogues of pyrethrins, which arenaturally produced by flowers of certain species of chrysanthemum (Chrysanthemum cinerariaefolium). They are usedextensively for the control of arthropod pests of agricultural crops andvectors of animal and human disease.
Thefirst commercial pyrethroids (discovered at Rothamsted), werebioresmethrin, permethrin, cypermethrinand deltamethrin. In this review article ,we will be studying the effect onearthworm metabolomics induced by pyrethroid use in agricultural land asinsecticide. Metabolomics has facilitated the identification of novel compoundsin earthworm tissue extracts which may be indicative of specific metabolismchanges resulting from chemical exposure.We will review the work studied onsome important biomarkers like aminoacids ,carbohydrates like glucose ,maltose, IMP (inosine monophosphate ), HEFS(2-hexyl-5-ethyl-3- furansulfonate) etc in earthworm’s different species. Wewill focus on the different techniques which can be used to study themetabolite profiles.