It was originally
thought that psychosis was the main consequence of aberrant salience, however
recent discoveries have reported that negative symptoms may arise due to the
overstimulation of irrelevant stimuli. Taking this into account, research into
non-medicated patients using fMRI scans of neurological networks within the
brain found that reduced activation in the ventral-striatal caused individuals
to respond to irrelevant stimuli, leading to both high risk psychosis, and
negative symptoms. This suggests that individuals may become less interested in
relevant stimuli over time due to interference in the processing of the reward
system in the ventral striatum (Juckel et al., 2006). Therefore, the literature
indicates that aberrant salience contributes to the presence of both positive
and negative symptoms in schizophrenics.