Dengue, amosquito borne seasonal viral infection.
Four closely related virus (DENV 1, 2,3, 4) are the causative agent of Dengue fever and are transmitted by the femalemosquito of genus Aedes. Through Dengueinfects nearly 50-220 million people annually, yet there is no specific cureavailable for Dengue yet studies on the extract of Carica papaya contains activecompounds vis: chymopapain and papain and other plants such as Psidium guavahave immunostimulant property contains quercetin which increases platelets andavoid bleeding, Andrographis paniculata have methanolic extract whichreported the highest antiviral inhibitory effect on DENV-1 by antiviral assaybased on cytopathic effects,Aquous extract of Azidarachta indica haveinhibitory potential on the replication of DENV-2, methanolicextract of Momordica charantia reported inhibitory effect on DENV-1,ethanolic extract of Rhizophora apiculata acts to inhibit theformation of enzyme mRNA in the virus and have inhibitory effect onDENV-2,Gastrodia elata B1 has effect on the multiplication cycle of DENV-2, It is reported that two compounds1-beta-D-ribofuranosyl-3-ethynyl-1,2,4 triazole (ETAR) and1-beta-Dribofuranosyl-4-ethynyl1,3 imidazole (IM18), significantly reducedreplication of dengue virus serotype 2 (DENV-2) in cultured Vero cells and anoval trypsin Kazal-type inhibitor from Aedes aegypti hasthrombin coagulant inhibitory activity.These have been reported to possess effectivenessin terms of increasing platelets count.Exact study on the chemical composition of the above mentioned plantscan be a very helpful approach towards Dengue viral fever.
Chromatographictechniques such as high performance liquid chromatography and Fouriertransformation technique can be used to separate compounds. Insilico analysisof plant constituent can prove a novel way to design analogous, which areeffective towards this infection.Through medicinal approach, the chances of side effects which arisefrom convention drugs can be minimized to a certain level.